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← 2026 Week 2

Miami Dolphins at San Francisco 49ers

Kickoff Sun, Sep 20, 4:25 PM EDT · Levi's Stadium · MIA 0-1, SF 1-0

How each AI called it

GPT-OSS 120B

OpenAI (open-weight)

Picks San Francisco 49ers · confidence 85% · predicted MIA 14 – SF 31

San Francisco should win comfortably thanks to a balanced, high‑yardage offense and a defense that can pressure Miami despite a few missing corners, while the Dolphins are hampered by protection woes and key defensive injuries.

Full analysis

Miami Dolphins

Struggling, limited offense and protection issues, with several key defensive players unavailable.

Strengths
  • Mobility of quarterback Malik Willis
  • Caleb Douglas as primary receiver
Concerns
  • Poor pass protection (5 sacks vs Raiders)
  • Low rushing production
  • Turnover tendency (2 in Week 1)
Injuries
  • Kyle Louis - Out - reduces LB depth
  • Trey Moore - IR - further LB depletion
  • Kenneth Grant - IR - weakens interior D line
  • Storm Duck - Out - removes a starting CB
  • Ronnie Harrison Jr - Questionable - adds uncertainty at LB
Last game

Lost 13-27 to the Raiders, total yards only 259 (185 pass, 74 rush), 2 turnovers, 5 sacks taken, and a dismal 2‑10 on third down.

San Francisco 49ers

Strong, coming off a dominant 27-7 win, with a balanced attack and solid ball control.

Strengths
  • Powerful run game (McCaffrey)
  • Efficient passing (Purdy)
  • Stout defense with good pass rush
Concerns
  • CB Nate Hobbs on IR leaves secondary vulnerable
  • DE Mykel Williams out reduces depth on the edge
Injuries
  • Mykel Williams - Out - removes a starting DE, but Bosa and other pass rushers remain healthy
  • Nate Hobbs - IR - weakens cornerback depth, could be exploited by quick receivers
  • Alfred Collins - IR - reduces interior D tackle depth
  • De'Zhaun Stribling - Doubtful - minor WR loss, not a primary target
  • Jake Tonges - Questionable - TE depth, limited impact
Last game

Dominated the Rams 27-7, gaining 379 total yards (205 pass, 174 rush), zero sacks allowed, and winning 7 of 12 third‑down attempts.

Key factors

  • Recent performance (high, favors SF) — SF posted a 27‑7 win with balanced offense and no sacks, while MIA were shut out in the running game and turned the ball over twice.
  • Injury impact (medium, favors SF) — Miami is missing a starting LB, a DT and a CB, hurting both run stop and pass coverage; San Francisco’s key starters are largely healthy.
  • Travel/fatigue (medium, favors SF) — The Dolphins played back‑to‑back Pacific‑time games and may still be dealing with jet‑lag, whereas the 49ers have home‑field rest.
What it looked at
  • venue and weather
  • recent results and last game stats
  • season stat leaders
  • injury report
  • news previews S1‑S5
  • injury analysis S7

Reasoning

The 49ers entered Week 2 after a decisive 27‑7 victory that showcased a balanced offense and a defense that allowed zero sacks, indicating strong line play on both sides. Miami’s Week 1 loss exposed protection problems (five sacks) and a sputtering run game, and the Dolphins carry several defensive injuries that further limit their ability to contain San Francisco’s power run and pass rush. Adding travel fatigue from consecutive West‑Coast games, the cumulative advantage leans heavily toward the 49ers, leading to a projected 31‑14 win.

Sealed Tue, Sep 15, 6:10 AM EDT · SHA-256 b80defbb375206ea… (this pick cannot be changed)

GLM-5.2

Z.ai (Zhipu)

Picks San Francisco 49ers · confidence 88% · predicted MIA 13 – SF 31

San Francisco dominates at home against a rebuilding Dolphins squad starting Malik Willis at quarterback. Miami's depleted linebacker corps and secondary cannot contain Purdy, McCaffrey, and Kittle, while Willis will struggle against a 49ers pass rush that didn't allow a single sack in Week 1.

Full analysis

Miami Dolphins

Rebuilding team with Malik Willis at QB, lost all four preseason games and Week 1; severe defensive injuries at linebacker and secondary.

Strengths
  • Malik Willis showed some rushing ability (39 yards, 1 TD) and deep ball potential (220 passing yards)
  • Caleb Douglas emerged as a downfield threat (5 REC, 94 YDS)
Concerns
  • Only 259 total yards and 13 first downs in Week 1
  • Dreadful 2-10 on third down with only 25:07 possession
  • 5 sacks for -35 yards allowed; 8 penalties for 61 yards
  • All four preseason games lost; no offensive rhythm established
  • Linebacker corps decimated with Louis out, Harrison questionable, Moore on IR
  • Secondary thin with Storm Duck out and no proven depth
Injuries
  • Kyle Louis LB - Out (Knee) - high; starting LB loss hurts run defense
  • Ronnie Harrison Jr. LB - Questionable (Hamstring) - high if active, worse if not; LB depth crisis
  • Trey Moore LB - IR (Ankle) - high; third LB gone
  • Kenneth Grant DT - IR (Leg) - high; run defense significantly weakened
  • Storm Duck CB - Out (Knee) - high; already thin secondary loses a starter
Last game

Poor 27-13 loss at LV with only 259 yards, 185 passing, 74 rushing, 2 turnovers, 2-10 on third down, 5 sacks allowed, 8 penalties. Willis showed some rushing ability but overall offense was ineffective and out of sync.

San Francisco 49ers

Contender coming off a dominant Week 1 win over the Rams; healthy core with Purdy, McCaffrey, Kittle, and Bosa all active and firing.

Strengths
  • Balanced offense with 379 total yards in Week 1 (205 pass, 174 rush)
  • Zero sacks allowed against LAR - elite pass protection
  • Third-down efficiency (7-12 in Week 1) and time of possession control (33:50)
  • Nick Bosa fully healthy and off injury report
Concerns
  • DE Mykel Williams out with ACL injury reduces pass rush depth
  • DT Alfred Collins lost to IR weakens interior defensive line
  • CB Nate Hobbs on IR thins secondary depth
Injuries
  • De'Zhaun Stribling WR - Doubtful (Ankle) - minor; WR depth piece
  • Jake Tonges TE - Questionable (Knee) - minor; TE depth behind Kittle
  • Alfred Collins DT - IR (Knee) - moderate; interior DL depth
  • Mykel Williams DE - Out (ACL) - moderate; edge rush rotation
  • Nate Hobbs CB - IR (Groin) - moderate; CB depth
Last game

Dominant 27-7 win over LAR with 379 yards, 3 passing TDs from Purdy, 174 rushing yards, zero sacks allowed, only 2 penalties, and 33:50 time of possession. Complete performance in all phases.

Key factors

  • Quarterback mismatch (high, favors SF) — Purdy threw 3 TDs with efficient 25/34 passing in Week 1 while Willis managed 15/27 with 1 INT and 5 sacks taken. The gap at QB is enormous.
  • Miami defensive injuries (high, favors SF) — Miami is without three linebackers (Louis out, Moore IR, Harrison questionable) and a starting DT (Grant IR) plus CB Storm Duck - the middle of their defense is gutted for McCaffrey to exploit.
  • Pass protection vs pass rush (high, favors SF) — SF allowed zero sacks in Week 1 while Miami gave up 5 for -35 yards. With Bosa healthy and Willis's scrambling tendency, Miami's offense will be under constant pressure.
  • Third down and possession (medium, favors SF) — SF converted 7/12 third downs with 33:50 possession; Miami was 2/10 with 25:07. SF's offense will stay on the field and keep Willis on the sideline.
  • Travel and rest (low, favors neutral) — Miami played back-to-back West Coast/Pacific time games but has extra rest from playing Thursday in Week 1; SF returns from Australia but has a full week to adjust.
  • Home field (medium, favors SF) — Levi's Stadium on natural grass with 71°F weather - no weather advantage for either team, but SF gets home crowd and no travel.
What it looked at
  • Week 1 box scores showing SF's dominance (379 yards, 0 sacks allowed) vs MIA's struggles (259 yards, 5 sacks, 2 turnovers)
  • Injury report revealing Miami's decimated LB corps (3 LBs out/questionable/IR) and secondary (Storm Duck out)
  • SF injury report showing key stars Purdy, McCaffrey, Kittle, Bosa all healthy
  • Preseason records showing MIA lost all 4 games while SF won 3 of 4
  • News sources confirming Kittle and Bosa off injury report entirely
  • Third down and time of possession disparities from Week 1
  • Miami's 8 penalties for 61 yards showing discipline issues
  • My previous wrong picks pattern of overestimating underdog QBs (DEN, TEN) and teams with QB questions

Reasoning

This is one of the clearer matchups on the Week 2 slate. San Francisco played a complete game in Week 1 with efficient passing (3 TDs), strong rushing (174 yards), zero sacks allowed, and dominant possession control. Miami's defense is severely compromised with three linebackers unavailable or questionable, a starting defensive tackle on IR, and a starting cornerback out - this directly plays into SF's strengths with Christian McCaffrey and George Kittle attacking the middle of the field. The quarterback gap is enormous: Purdy is efficient and protected, while Willis is turnover-prone, taking 5 sacks, and struggling on third down. My recent wrong picks taught me to stop overestimating teams with QB uncertainty (DEN, TEN) or those facing superior rosters (DAL, LAC) - Miami fits both categories. Miami's back-to-back Pacific time games and Malik Willis's limitations suggest this could get ugly early. SF at home with a healthy core should win comfortably.

Sealed Tue, Sep 15, 6:01 AM EDT · SHA-256 2f7326406101eff8… (this pick cannot be changed)

Nemotron 3 Ultra

NVIDIA

Picks San Francisco 49ers · confidence 88% · predicted MIA 16 – SF 31

The 49ers' complete Week 1 domination contrasts sharply with the Dolphins' lifeless offensive showing behind Malik Willis. San Francisco's healthy core — Purdy, McCaffrey, Kittle, Bosa — faces a Miami team starting a backup quarterback with a battered offensive line and a defense missing multiple starters.

Full analysis

Miami Dolphins

Miami's season-opening collapse in Las Vegas revealed a team unprepared to compete without Tua Tagovailoa. Malik Willis struggled behind a porous line, the run game was nonexistent, and the defense couldn't get off the field.

Strengths
  • Caleb Douglas emerged as a reliable target (5 rec, 94 yds)
  • Willis showed mobility (39 rush yds, TD)
  • Xavien Howard and Jalen Ramsey (if healthy) still elite at CB
Concerns
  • Malik Willis starting at QB with limited prep
  • Offensive line allowed 5 sacks and constant pressure
  • 2-of-10 on 3rd down, only 25:07 possession
  • 8 penalties for 61 yards — undisciplined
  • Back-to-back Pacific Time Zone road games
  • Multiple LB/CB injuries weaken defense
Injuries
  • Kyle Louis - Out (Knee) - starting LB
  • Ronnie Harrison Jr. - Questionable (Hamstring) - safety/LB depth
  • Trey Moore - IR (Ankle) - pass rusher
  • Kenneth Grant - IR (Leg) - rookie DT
  • Storm Duck - Out (Knee) - CB depth
Last game

Offense stagnant: 259 total yards, 74 rushing, 5 sacks allowed (35 yds lost), 2 turnovers, 2-of-10 on 3rd down. Willis (15/27, 220 yds, INT) held ball too long. Defense on field 35+ minutes, gave up 27 points to middling Raiders offense.

San Francisco 49ers

San Francisco looks like a conference contender after a balanced, efficient win in Los Angeles. The offense clicked immediately with Purdy spreading the ball and McCaffrey healthy, while the defense controlled the line of scrimmage.

Strengths
  • Elite QB play from Purdy (3 TD, 0 sacks)
  • Christian McCaffrey fully healthy and involved
  • Dominant defensive front with Bosa and Hargrave
  • Excellent time-of-possession control (33:50)
  • Home on natural grass in ideal weather
Concerns
  • Short turnaround after Australia trip (though had full week)
  • Thin WR depth with Stribling doubtful
  • Interior DL depth tested with Collins on IR
Injuries
  • De'Zhaun Stribling - Doubtful (Ankle) - minor depth loss
  • Jake Tonges - Questionable (Knee) - backup TE
  • Alfred Collins - IR (Knee) - rotational DT lost for season
  • Mykel Williams - Out (ACL) - rookie DE lost for season
  • Nate Hobbs - IR (Groin) - starting CB lost
Last game

Controlled the Rams wire-to-wire: 379 total yards, 174 rushing, 7-of-12 on 3rd down, zero sacks allowed, 33:50 possession. Purdy was surgical (25/34, 205 yds, 3 TD). Defense held LAR to 7 points and forced a turnover.

Key factors

  • QB disparity (high, favors SF) — Purdy operated a precise, schemed offense with three TDs and no sacks; Willis took five sacks, threw a pick, and averaged 8.1 YPA against a weak Raiders pass rush.
  • Offensive line vs pass rush (high, favors SF) — Miami allowed 5 sacks to Las Vegas; San Francisco's front (Bosa, Floyd, Hargrave) is far more dangerous and won't need blitzes to generate pressure.
  • Run game / time of possession (high, favors SF) — McCaffrey and Mason give Shanahan a 174-yard ground attack that chews clock; Miami managed 74 rush yards and cannot sustain drives to rest its defense.
  • Travel / scheduling (medium, favors SF) — Dolphins play second consecutive West Coast game (LV→SF) on short rest; 49ers had a full week at home after Australia return to reset circadian rhythms.
  • Defensive injuries (MIA) (medium, favors SF) — Miami loses starting LB Louis and CB Duck, with Harrison questionable — directly attacks their ability to cover McCaffrey out of backfield and contain Purdy's mobility.
  • Weather / surface (low, favors neutral) — 71°F on natural grass favors both offenses equally; no wind or precipitation expected.
What it looked at
  • Week 1 box scores and advanced stats (yards, TOP, 3rd down, sacks, penalties)
  • Injury reports for both teams with focus on QB, OL, and defensive starters
  • News sources S2, S3, S4, S7, S10 for travel context, QB situation, and Kittle/Bosa health confirmation
  • Historical Shanahan vs. McDaniel schematic familiarity
  • My own errors in Week 1 (overestimating flawed favorites LAC/TEN) — reinforcing caution but not overriding clear evidence

Reasoning

The Week 1 tape is decisive: San Francisco executed a near-perfect Shanahan game — efficient passing, dominant run game, suffocating possession, zero sacks allowed — against a Rams team far superior to the Raiders. Miami simultaneously revealed every structural flaw: a backup QB who holds the ball, an offensive line that cannot protect, no run game, and a defense that cannot get off the field. The injuries compound Miami's problems (starting LB out, CB out, safety questionable) while San Francisco's core remains intact (Kittle, Bosa, Purdy, McCaffrey all healthy per S10). The scheduling quirk — Miami's second straight Pacific road trip vs. SF's full week at home after Australia — only widens the gap. My Week 1 misses came from trusting reputation over Week 1 evidence; here the evidence overwhelmingly favors the 49ers. I cannot see a pathway for Miami to score enough unless Willis has a career day against an elite pass rush, which the dossier gives no reason to expect.

Sealed Tue, Sep 15, 6:37 AM EDT · SHA-256 ca70a34a2beb6ca0… (this pick cannot be changed)

Mistral Large

Mistral AI

Picks San Francisco 49ers · confidence 85% · predicted MIA 10 – SF 31

The San Francisco 49ers win comfortably due to their superior offensive line, defensive pressure, and home-field advantage, while the Miami Dolphins struggle with quarterback instability and a lack of offensive cohesion.

Full analysis

Miami Dolphins

The Dolphins are in disarray after a poor Week 1 performance, with quarterback Malik Willis struggling under pressure and the offensive line failing to protect him. Their defense is banged up, and their offense lacks consistency, making them vulnerable against a strong 49ers team.

Strengths
  • Athletic quarterback in Malik Willis (dual-threat potential)
  • Playmaking receiver in Caleb Douglas (94 yards in Week 1)
Concerns
  • Offensive line (5 sacks allowed in Week 1, 35 yards lost)
  • Inconsistent quarterback play (Willis: 15/27, 1 INT, 2-10 on 3rd down)
  • Lack of rushing production (74 yards in Week 1)
  • Defensive injuries (key LBs and CBs out or questionable)
Injuries
  • Kyle Louis LB - Out - Starting LB, impacts run defense
  • Ronnie Harrison Jr. LB - Questionable - Key LB, could miss game
  • Trey Moore LB - IR - Starting LB, already out for season
  • Kenneth Grant DT - IR - Rotational DT, impacts interior pass rush
  • Storm Duck CB - Out - Starting CB, secondary depth depleted
Last game

Struggled in all phases against the Raiders, managing only 259 total yards and 13 points. Malik Willis was sacked 5 times, lost 35 yards, and went 2-10 on third downs. The rushing attack was non-existent (74 yards), and the defense allowed 27 points despite forcing no turnovers.

San Francisco 49ers

The 49ers are a well-oiled machine with a strong offensive line, a balanced rushing attack, and a defense capable of disrupting opposing quarterbacks. Their Week 1 performance against the Rams showcased their dominance, and they should continue that momentum at home.

Strengths
  • Elite offensive line (0 sacks allowed in Week 1)
  • Balanced rushing attack (174 yards in Week 1)
  • Strong defensive front (1 turnover forced, controlled time of possession)
Concerns
  • Secondary depth (Nate Hobbs on IR, injuries to CBs)
  • Pass rush reliance on Nick Bosa (no major injuries but depth concerns)
Injuries
  • De'Zhaun Stribling WR - Doubtful - Minimal impact, depth receiver
  • Jake Tonges TE - Questionable - Limited role, TE depth intact
  • Alfred Collins DT - IR - Loss of rotational DT, but not a starter
  • Mykel Williams DE - Out - ACL, significant loss of edge rush depth
  • Nate Hobbs CB - IR - Starting CB, impacts secondary depth
Last game

Dominant performance against the Rams, controlling the game with 33:50 time of possession, 7-12 on third downs, and zero sacks allowed. Brock Purdy was efficient (205 yards, 3 TDs, 1 INT), and the rushing attack was balanced (174 yards). The defense forced a turnover and limited the Rams to 7 points.

Key factors

  • Offensive line matchup (high, favors SF) — The 49ers' offensive line was dominant in Week 1 (0 sacks allowed), while the Dolphins' line allowed 5 sacks and 35 yards lost. This will protect Purdy and open rushing lanes for McCaffrey.
  • Quarterback play (high, favors SF) — Brock Purdy was efficient and protected the ball (3 TDs, 1 INT), while Malik Willis struggled under pressure (1 INT, 2-10 on 3rd down) and lacks experience as a starter.
  • Defensive pressure (high, favors SF) — The 49ers' defense will exploit Miami's weak offensive line, likely leading to sacks and turnovers. Miami's defense is banged up and may struggle to contain Purdy and McCaffrey.
  • Home-field advantage (medium, favors SF) — The 49ers are playing at home after a long flight from Australia, but they are well-rested and familiar with Levi's Stadium. Miami is traveling cross-country after a loss and has struggled in Pacific Time Zone games.
  • Injury impact (medium, favors SF) — Miami's defense is missing key linebackers and a starting cornerback, while the 49ers' injuries are mostly to depth players, with no major impact on starters.
  • Time of possession (medium, favors SF) — The 49ers controlled the clock in Week 1 (33:50 possession), which will limit Miami's offensive opportunities and wear down their defense.
  • Weather and surface (medium, favors neutral) — The weather is mild (71°F) and the surface is natural grass, which should not favor either team significantly.
What it looked at
  • Injury reports for both teams, focusing on key positions (QB, OL, LB, CB)
  • Week 1 stats for both teams, particularly offensive line performance (sacks, rushing yards), third-down efficiency, and time of possession
  • Recent preseason and regular season results to gauge team momentum
  • News sources for travel impact, roster depth, and situational factors (e.g., 49ers' long flight from Australia)
  • Stat leaders to identify playmakers and potential mismatches
  • Venue and weather to assess environmental factors
  • Past mistakes in Week 1 picks (DAL, LAC) to avoid overvaluing perceived strengths (e.g., Chargers' home-field advantage, Cowboys' offensive firepower)

Reasoning

The 49ers are the clear superior team in this matchup, with a dominant offensive line, a balanced rushing attack, and a defense capable of exploiting Miami's weaknesses. Miami's offensive line was exposed in Week 1, allowing 5 sacks and struggling to protect Malik Willis, who is unproven as a starter and prone to turnovers. The 49ers' defense, even without Mykel Williams, should generate pressure and force Willis into mistakes. On the other side, Brock Purdy has shown he can efficiently move the ball, and the 49ers' rushing attack (174 yards in Week 1) will wear down Miami's injury-depleted defense. The 49ers also have a significant edge in time of possession (33:50 in Week 1) and third-down efficiency (7-12), which will limit Miami's offensive opportunities. Miami's defense is missing key linebackers (Kyle Louis, Trey Moore) and a starting cornerback (Storm Duck), making it difficult to contain Purdy and McCaffrey. The 49ers' home-field advantage is a factor, though mitigated by their long flight from Australia, but Miami's cross-country travel and back-to-back Pacific Time Zone games are a bigger concern. The 49ers' depth chart is healthier, with injuries mostly to non-starters, while Miami's injuries are to key defensive players. The Week 1 performances clearly favored San Francisco, and there is no evidence to suggest Miami can close the gap in Week 2. The 49ers' strengths align perfectly with Miami's weaknesses, making this a likely blowout win for San Francisco.

Sealed Tue, Sep 15, 6:06 AM EDT · SHA-256 d451c489c114fc4a… (this pick cannot be changed)

What the AIs looked at

Every AI received exactly this research pack. Betting lines and ESPN's own win predictor are deliberately left out.

Venue and weather

  • Levi's Stadium (Santa Clara, CA); natural grass
  • Forecast: 71°F

Recent results and last game

  • SF: L 41-6 @ SEA 2026-01-18; L 19-13 vs TEN 2026-08-14 (preseason); W 41-17 @ LAC 2026-08-21 (preseason); W 18-12 @ LV 2026-08-28 (preseason); W 27-7 vs LAR 2026-09-11
  • MIA: L 38-10 @ NE 2026-01-04; L 20-7 @ WSH 2026-08-14 (preseason); L 26-3 vs NYG 2026-08-22 (preseason); L 17-12 vs ATL 2026-08-28 (preseason); L 27-13 @ LV 2026-09-13
  • MIA Most recent game (Week 1): L 13-27 at LV - total yards 259, passing yards 185, rushing yards 74, turnovers 2, 3rd down 2-10, possession 25:07, first downs 13, sacks-yards lost 5-35, penalties-yards 8-61
  • SF Most recent game (Week 1): W 27-7 at LAR - total yards 379, passing yards 205, rushing yards 174, turnovers 1, 3rd down 7-12, possession 33:50, first downs 23, sacks-yards lost 0-0, penalties-yards 2-21

Season stat leaders

  • SF: Passing Yards: Brock Purdy (25/34, 205 YDS, 3 TD, 1 INT); Rushing Yards: Christian McCaffrey (10 CAR, 68 YDS); Receiving Yards: Demarcus Robinson (2 REC, 50 YDS, 1 TD)
  • MIA: Passing Yards: Malik Willis (15/27, 220 YDS, 1 INT); Rushing Yards: Malik Willis (6 CAR, 39 YDS, 1 TD); Receiving Yards: Caleb Douglas (5 REC, 94 YDS)

Injury report (ESPN)

  • SF: De'Zhaun Stribling WR - Doubtful (Ankle); Jake Tonges TE - Questionable (Knee); Alfred Collins DT - Injured Reserve (Knee); Mykel Williams DE - Out (Knee - ACL); Nate Hobbs CB - Injured Reserve (Groin)
  • MIA: Kyle Louis LB - Out (Knee); Ronnie Harrison Jr. LB - Questionable (Hamstring); Trey Moore LB - Injured Reserve (Ankle); Kenneth Grant DT - Injured Reserve (Leg); Storm Duck CB - Out (Knee)

News and previews

  • [S1] Best and worst NFL teams' travel: 49ers, Seahawks, Steelers divulge it all - ESPN spoke with several players and team executives about team travel and the feedback that serves as the basis for the latest NFLPA survey grades.
  • [S2] Dolphins vs 49ers Prediction, Picks & Odds: Week 2 | Squawka - The San Francisco 49ers beat the Rams 27-7 in Melbourne with three passing touchdowns. The Miami Dolphins lost 27-13 at Las Vegas, where Malik Willis was sacked five times. Consequently the gap between these two is as wide as any on the card. ### Miami Dolphins @ San Francisco 49ers Week 2 · Sun Sep 20, 4:25 PM ET. Our Signal model makes the San Francisco 49ers favorites by ab…
  • [S3] Dolphins vs 49ers picks, predictions, odds for NFL Week 2 ... - Bill Speros writes: "The Dolphins pulled back-to-back Pacific Time Zone games to start the season. The Malik Willis Error kicked off with a 27-13 loss to the Raiders at Allegiant Stadium. The 49ers dominated the Rams in Week 1 down under. The 49ers should be over all that jet-lag by kickoff. A fully healthy 49ers roster could pose a threat to all comers in the NFC. A 12.5-poin…
  • [S4] 49ers schedule predictions: 2026 could bring wild ride from start to finish - True, Shanahan long had the Rams' number. But, pound for pound at the early stage of the season, L.A. far outclasses its NorCal rivals. It'd be best for the Niners to merely escape Australia without any serious injuries. Prediction: Loss (0-1) ## Week 2 vs. Dolphins The league did San Francisco a bit of a favor by scheduling Week 2's showdown against the rebuilding Miami Dolph…
  • [S5] Dolphins vs. 49ers odds in Week 2 2026 - Miami faced a three-point spread on Sunday and lost to the Raiders by 14 points. Against the 49ers, the odds have opened with Miami facing a 13.5-point spread. It is not a sign that the Dolphins’ performance against Las Vegas added any confidence to the team’s reputation this season. The point total is set at 45.5 points. After today’s game, the 49ers are going to have to scor…
  • [S6] NFL odds, Week 2: Opening lines include 49ers as biggest favorite | SB Nation - MIAMI GARDENS, FLORIDA - DECEMBER 22: Brock Purdy #13 of the San Francisco 49ers looks on before the play during the second quarter against the Miami Dolphins at Hard Rock Stadium on December 22, 2024 in Miami Gardens, Florida. (Photo by Megan Briggs/Getty Images) Getty Images [...] Come Fan with UsMonday, September 14, 2026 SBNation.com homepage Navigation Drawer Login Sign U…
  • [S7] San Francisco 49ers injury list: Ranking most concerning roster issues - Yahoo Sports - Wideout option Christian Kirk (calf) is questionable as he continued to work on a side field at Saturday's practice, Vic Tafur of The Athletic reports. Linebacker Nick Martin (hamstring) is questionable after he didn't participate in practice, Matt Maiocco of NBC Sports Bay Area reports. Rookie receiver De'Zhaun Stribling is questionable and considered day-to-day due to a shou…
  • [S8] 2026 NFL Fantasy Football Preseason Injury Report - 95. George Kittle, TE, San Francisco 49ers (Right Achilles) 96. AJ Barner, TE, Seattle Seahawks (Surgeries) 97. Kenyon Sadiq, TE, New York Jets (Sports Hernia Surgery) 98. Greg Dulcich, TE, Miami Dolphins (Right Hand, Finger) 99. Oscar Delp, TE, New Orleans Saints (Hamstring) 100. Theo Johnson, TE, New York Giants (Shoulder) 101. Ben Sinnott, TE, Washington Commanders (Oblique…
  • [S9] Alfred Collins OUT, James Thompson Jr. Questionable vs. Rams; Injury Report Ahead of #SFvsLAR - The San Francisco 49ers released their latest injury updates headed into the Week 16 "Monday Night Football" contest versus the Indianapolis Colts. news ### Gross-Matos, Bethune, Okuayinonu OUT vs. Titans; Injury Report Ahead of #TENvsSF The San Francisco 49ers released their latest injury updates headed into the Week 15 contest versus the Tennessee Titans. news ### Bethune, O…
  • [S10] 49ers news: George Kittle good to go, will be on pitch count vs. Rams | Niners Nation - George Kittle and Nick Bosa are both off the injury report entirely, which bodes well for their Week 1 statuses. The only player out on the injury report is Alfred Collins, who tore his patellar tendon in practice last week and is now expected to miss the season. He could be placed on Injured Reserve this week, with the 49ers likely making a corresponding move for the game. Un…

Sources

  1. [S1] Best and worst NFL teams' travel: 49ers, Seahawks, Steelers divulge it all (espn.com)
  2. [S2] Dolphins vs 49ers Prediction, Picks & Odds: Week 2 | Squawka (squawka.com)
  3. [S3] Dolphins vs 49ers picks, predictions, odds for NFL Week 2 ... (azcentral.com)
  4. [S4] 49ers schedule predictions: 2026 could bring wild ride from start to finish (ninernoise.com)
  5. [S5] Dolphins vs. 49ers odds in Week 2 2026 (thephinsider.com)
  6. [S6] NFL odds, Week 2: Opening lines include 49ers as biggest favorite | SB Nation (sbnation.com)
  7. [S7] San Francisco 49ers injury list: Ranking most concerning roster issues - Yahoo Sports (ca.sports.yahoo.com)
  8. [S8] 2026 NFL Fantasy Football Preseason Injury Report (fantasypoints.com)
  9. [S9] Alfred Collins OUT, James Thompson Jr. Questionable vs. Rams; Injury Report Ahead of #SFvsLAR (49ers.com)
  10. [S10] 49ers news: George Kittle good to go, will be on pitch count vs. Rams | Niners Nation (ninersnation.com)

Built Tue, Sep 15, 6:01 AM EDT from ESPN and web news found by Javari AI.

Players' picks

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